Biossimilars, Are they Really Cost Saving? The Case of Recombinant Human Follicle Stimulating Hormone in Portugal

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P-98: The Effect of Primary pH Values of Medium Culture on Expression of Human Follicle Stimulating Hormone in Recombinant Chinese Hamster Ovary Cells.

Background One of the common gonadotropin hormones used for infertility treatment is recombinant Follicle stimulating hormone (rFSH). pH is an environmental factor that can affect production of recombinant proteins with no imposing cost. Culture pH is known as a parameter that significantly affects cell growth and protein production. In this study, tried to investigate the effect of different p...

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Overnight radioimmunoassay of human follicle-stimulating hormone.

A radioimmunoassay procedure for follicle-stimulating hormone in serum has been developed in which the assay mixture is incubated at 37#{176}C for a total of 22 h, rather than at 4#{176}C for 4-7 days. The withinassay coefficients of variation for the 37#{176}C and 4#{176}C methods, respectively, are 7.7% and 5.0%, while the between-assay variations are 13.8% and 9.9%. Comparison of values for ...

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Follicle-stimulating hormone and human spermatogenesis.

The role of follicle-stimulating hormone (FSH) in the control of spermatogenesis is not well established in any species, including man. We studied the effect of an experimentally-induced, selective FSH deficiency on sperm production in normal men. After a 3-mo control period, five normal men received testosterone enanthate (T) 200 mg i. m. weekly to suppress luteinizing hormone (LH) and FSH, un...

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Meta-analysis on recombinant versus urinary follicle stimulating hormone.

A recent meta-analysis (Daya and Gunby, 1999) on recombin-ant versus urinary follicle stimulating hormone (rFSH versus uFSH) deserves methodological comment. The a priori definition of eligibility criteria for studies to be included in a meta-analysis are central and must be systematic. It was up to the authors to decide whether their search would be extended to include all unpublished studies,...

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ژورنال

عنوان ژورنال: Value in Health

سال: 2015

ISSN: 1098-3015

DOI: 10.1016/j.jval.2015.09.2820